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I was big into MIRVs before I started playing around with bouncing bettys. I currently have a firey bouncing betty mod which I can toss one or two into a room and watch them shoot all the enemies and set them on fire. The resulting red numbers flying off into the air is incredibly satisfying to watch. MIRVs can be insanely destructive, no doubt, but they explode, do big numbers and then everything is dead. Effective, certainly. I just find something about watching all those numbers fly much more satisfying though.
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I was all about Transfusion grenades for the longest time. Then I found some sick Homing Tesla grenades, and have used them ever since. They help so much in TVHM, since everyone (almost) has shields. Stalkers fall quick as well.
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Continious damage grenades for the win. Spamming them always solve the problem, no matter what. Ultimate Badass Varkid? Fire spray. Ultimate Badass Constructor? Corrosive cloud (Or Pandemic, if possible). Tiimon? Tesla.
Huge fan of Homing Corrosive MIRV Transfusion myself. With the least fuse time as possible. Not only does the grenade home in and blow up, but then each child grenade also homes and then blows up with corrosive damage, and then heals me.
Stop taking exactly what I'm saying and repeating it as if its exactly what I said because it is. -Cryptospuridium