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I used a combination rampage/brawn build. I really liked the health regen of the Neogenator sheild combined with the health regen of Sal's other abilities. The sheild is small but the +health and +health regen is nice. The bee is nice for just plain extra damage. When I run through the normal mode, I like using the Impaler spike sheild.
As for weapons, it changes depending on what I want to do and what mod/relic I'm running.
I have two vladof anarchist pistols (purple, ~10k dmg, ~87%acc, ~10 firerate, ~27 mag)that I like to use in combination with the Titan class mod and pistol dmg relic.
Sometimes I like to use the launcher/torgue gunzerk glitch for fun.
For bosses, I usually use the bee sheild+babymaker with the +team magazine mod and the +health relic just for the sake of expediency.
Fact because it's science. ==============================================