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You realy need a good build for the second playthrough. Crap gets realy tough. Even if you dupe money till you have all 9's, and gamble till you have awsome stuff. it makes no difference chances are you'll get dead a lot. Right now I'm playing through again with a comando and the mechro, so I'll have 3 charcters ready to do the second playthrough. Ya I farm the box evry 10 levels or so, and i use a gunzerker as a mule for duping and ammo regen. This game is wicked fun, I can't wait to see what I find at level 50.
"The last thing that you see is the hunger in my eyes."