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I recently installed FO3 but I haven't got a chance to play due this weird bug. When I try to start a new game, then game crashes while it's loading. I googled something like this: Game crashing when ”New Game” is pressed in the main menu (related to ffdshow - adding fallout3.exe to the exception list off directshow audio/video apparently fixes this, but still remains an issue with others).
But that doesn't really solve my problem, since I don't think I have ffdshow, or whatever. Or at least I don't know where I could access those options.
My specs are: E6750 (dual core, 2,66 GHz), 8600GT and 2 gigs RAM.
You'd probably be better off running a dxdiag and posting it on the official forums. You could try searching this forum, but I don't remember seeing anyone with that problem. I had to get the patch, then update my drivers, and I've been running smooth since then. But, I had random CTDs, not when trying to start a new game.