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Apparently it becomes a safehouse later in the game.
I think there's some confusion here. The Wiki link looks like a house that does become a safehouse, but your in-game pic is Mad Dog's house across the street from it. That one doesn't become a safehouse, but you can save your game there after a mission that takes place inside.
Are there later missions that end up in the interior of the Chemosphere?
Are any of the other houses in the game (Particularly in the Vineland/Hollywood Hills area) based on real, famous homes?
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Though this photo suggests that his most famous photo of the house (The women in the house at night chatting with the city lights behind them) was taken with his feet in the pool: http://www.flickr.com/photos/geezopeez/257907345/
-------- I admit I'm a little disappointed there's no point in the game where you get to go in the Chemosphere, because with the Grand Theft Auto designers' obsession with movies, including it in the game is almost certainly a reference to BODY DOUBLE, and, it'd be a great place for an Easter Egg or joke of some kind (like a telescope). I wonder if there's any sort of noclipping way to get through the wall just to see if there's something hidden inside.