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First thing that came to mind (aside from the aforementioned Sonic the Hedgehog 2) was the old series of computer role-playing games, Ultima, primarily III ("Exodus"), IV ("Quest of the Avatar"), V ("Warriors of Destiny"), VI ("The False Prophet"), and VII ("The Black Gate/Serpent Isle").
"Help! Help! They've destroyed my cousin's brain!! Oh, my god! They've already milked you, haven't they?!!" -- Phoncible P. Bone