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load a previous save, take out mods if you have them, and reinstall the game,
i had a problem where roughly 5 minutes into playing it would crash, so i took off all recent mods, and reinstalled, i had to end up manually going through my registry and deleting everything to do with just cause 2, after that it has been all fine,
I put the laughter in manslaughter PSN- tomma101 Australia, love it or leave it