You're browsing the GameFAQs Message Boards as a guest. Sign Up for free (or Log In if you already have an account) to be able to post messages, change how messages are displayed, and view media in posts.
Yes, you can just bypass all that running around. Manny just needs the ghouls gone, so kill everyone and you're fine. That's how I always do it. I'd also kill everything in the basement too... I don't think it matters but it's more exp and loot.