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Going along with the "trust no one" theme, I wonder if NPCs will try to point you in the wrong direction. The first kind of went that rout (with Adams), but you were pointed in a direction you needed to go anyway (well, you had no choice as that was the only way you could go). I think it would be cool if NPCs tried to convince you to do things that could make you fail (including multiple endings, or a simple game over), or at least get you to do things that would make life really dificult so you really don't know who to believe.