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But given how Ashley is still whining and complaining about you & Cerberus, I have to go with Tali.
Liara is the worst, not only does it not feel genuine. But she's obviously never heard of consistency. Only thing worse is how she's Bioware's pet so you could never kill her off, yet you can any other LI.
I'm partial to Jack since I think she goes pretty well with my renegade-with-a-heart-of-gold Shepard, but I don't really know who I would say is the best. I also liked Tali's romance in ME2 and I also kind of like Kaidan.
Its like having a knitting contest between the best regular old lady knitter in the world and a guy who's superpower is specifically to be the best knitter ever