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I really disagree with people saying grenades are bad off-host. Yeah the throw is delayed and occasionally they won't register/explode at all, but given that they have no cooldown and good splash damage I'd much rather have to rely on them than common projectile powers like Incinerate or Warp. Those often miss or travel directly through enemies, then leave you waiting with a cooldown.
For whatever it's worth, I usually don't host and this game has always laggy pretty terribly for me, and I use grenade classes maybe 3/4 of the time.
I never, ever host because of my terrible connection, and grenade classes can be very tricky if you're just throwing blanks all of the time. I do agree that they can be better than projectile powers though since most grenades will not miss their targets due to radius.