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Because you haven't played since Red/Blue I'd recommend grabbing HeartGold/SoulSilver. They're simply updated remakes of the original Gold/Silver (which were the sequels to Red/Blue). It's going to have a lot of pokemon you're familiar with so the game itself won't feel as overwhelming and foreign.
EDIT: And when you're done with the Gold/Silver portion of the game, you continue by playing through the region from Red/Blue!
TC, I would start with HG/SS because it is a good introduction to gen 2 pokes and then post game you can play with gen 4 pokes. The only thing I didn't like about HG/SS was the level scaling. Platinum is another good pick and B/W2 after that or just get B/W2 if you want to be current and play in wifi tournaments.
"In truth, they haven't been allowed for ages, we've just never enforced the rule" -SineNomine on presigs
Diamond/Pearl are honestly my favorites. Sinnoh's the best world to explore. BW are obviously more impressive visually, but Unova's too linear, and Gen 5's Pokemon were the first gen where I couldn't refute the stupid "POKEMON PAST 151 SUCK" people.
That said, I prefer Black/White 1 over the sequels. The mid-section of BW2 from Gyms 3-6 was really lazy and recycled, it went back to the generic story of pre-BW Pokemon games (arguably pre-DP), and though it had way more new content than the standard "3rd color" games like Yellow and Crystal, it still wasn't quite enough to satisfy a sequel.
But to answer the OP's question, go for Platinum, Black/White 1, or HeartGold/SoulSilver. Ideal versions of each generation to get you back into the series.
Black/White are good entry games, but their sequels, Platinum and HG/SS are better games.
What crack are you on? Platinum and HeartGold/SoulSilver came BEFORE Black/White and Black2/White2.
I think that was just poor wording on his part. I'm pretty sure that by "their sequels," he meant Black 2 and White 2.