The press calls it "gaming's first sitcom," we call it the world's first truly episodic game. Sam and Max: Season 1 is comprised of six self-contained game episodes that are tied together by a larger mystery that will emerge as the season builds to a climax. You can play the episodes in any order you want, but you'll appreciate the full story more if you start with Episode 1 and solve them in chronological order.
If you're stuck in Sam & Max: Save the World, ask your fellow GameFAQs members for help.
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